The purpose of this research was to formulate taste masked solid dispersions of mebeverine hydrochloride. A 41.31.21 full factorial design was applied for the preparation of twenty-four drug resonates formulae. Four carriers namely; eudragit E100, eudragit EPO, fructose and sacralose were used (variable X1) each at three drug-carrier ratios (1:5, 1:7 and 1:10), (variable X2). Two solvent evaporation techniques were applied either kneading-oven or rotovap method (variable X3). Solid dispersions were evaluated for taste masking using panel test and UV method, drug loading and in-vitro drug release in salivary and gastric pH. Formula prepared using eudragit E100 at 1:5 drug: carrier ratio by rotovap technique was the formula of choice. It showed the highest desirability factor and highest taste masking with immediate release in gastric pH as well as acceptable drug loading. Drug changed from crystalline to amorphous form as seen by the image analyzer and recorded in powder x-ray diffraction analysis. The characteristic drug peak and bands were significantly changed in DSC and FTIR spectra respectively proving physical and chemical interaction between drug and carriers.
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